NFL betting tips: San Francisco 49ers vs Los Angeles Rams preview and picks

With the bye weeks out of the way, the 2024 NFL season is nearing a thrilling conclusion and the San Francisco 49ers and Los Angeles Rams start Week 15 with what should be a cracking NFC West contest at Levi’s Stadium. Both teams are on the outside looking in as far as the playoffs are concerned – the Rams have a 7-6 record following last week’s brilliant 44-42 win over the Bills while the 6-7 49ers have work to do if they’re to repeat last season’s run to the Super Bowl. There is little between the two California franchises in the match betting for Thursday’s game but we’re favouring the Niners as part of a bet builder which pays out at 9/1. GET £20 IN FREE BETS WITH TALKSPORT BET* San Francisco 49ers v Los Angeles Rams tips San Francisco 49ers Handicap -2.5 Over 48.5 Total Match Points Brock Purdy 0ver 0.5 rushing touchdowns Bet Builder odds: 9/1 49ers should pull away on home turf This is a high-pressure clash in the context of both teams’ seasons but particularly the 49ers, who have no margin for error whatsoever given their losing record. While it’s not been a vintage season for Kyle Shanahan’s men, who have been hit by a series of injuries to key players on both offence and defence, they returned to top form in Week 14 to defeat the Chicago Bears and will view this as something of a free hit. The Rams have won the last two clashes, mounting a fourth-quarter comeback to win 27-24 in Week 3 of this season and winning 21-20 in Santa Clara in January last season, albeit in a game in which 49ers quarterback Brock Purdy was absent. Purdy has previously led the 49ers to victory over their divisional rivals, doing so at SoFi in September of the 2023 regular season, and he was at his clinical best against the Bears on Sunday, completing 80% of his passes for 325 yards and two touchdowns. LA are riding high after their victory over the Bills but that was an emotionally draining win for a team who have been inconsistent this season. Expect points to pile up in Santa Clara The total is set high at 48.5 but there is every chance these teams combine for a high-scoring contest at the Levi’s. The 49ers still boast a stout defence but Matthew Stafford and the Rams were good enough to go toe-to-toe with the Bills and, with wide receiver Puka Nacua in red-hot form, LA should help contribute to the scoring. The Rams have, however, struggled on the defensive side of the ball all season, allowing an average of 25.5 points per game. Niners QB Purdy could use his legs The 49ers running backs have been dropping like flies and doubts remain over the health of Isaac Guerendo, who was already filling in for Christian McCaffrey and Jordan Mason. Guerendo ran in two touchdowns against the Bears but he’s a doubt with a foot sprain, which could force Purdy to take matters into his own hands in the red zone. Purdy is no stranger to using his legs – he has had four rushing touchdowns this season – all of which came in the Niners last four home games. GET £20 IN FREE BETS WITH TALKSPORT BET* *18+ New customers only. Opt in & bet £10+ via mobile on any sports at 2.00+ odds within 7 days. No Cash out. Get 4x £5 Free Bets on selected markets. Free bets expire in 7 days. Card payments & Apple Pay only. T&Cs apply, see below. GambleAware.org | Please gamble responsibly All odds correct at time of writing talkSPORT BET Canada talkSPORT BET is now live in Canada! Following on from our success in the UK & Ireland, we have now launched in Canada. All residents outside of Ontario can now sign up and bet with talkSPORT BET. Bet $10 at odds of +100 and get triple your returns up to $300! – CLAIM HERE T&Cs: 19+ New customers only. Opt in, bet max $10 on any sport single in 7 days, at odds +100 or greater. If it wins we Triple (x3) your returns, up to $300 in Free Bets, expires in 7 days. T&Cs apply, click for T&Cs. Responsiblegambling.org | Please gamble responsibly Remember to gamble responsibly A responsible gambler is someone who: Establishes time and monetary limits before playing Only gambles with money they can afford to lose Never chase their losses Doesn’t gamble if they’re upset, angry or depressed Gamcare – www.gamcare.org.uk GambleAware – www.gambleaware.org Find our detailed guide on responsible gambling practices here. For help with a gambling problem, call the National Gambling Helpline on 0808 8020 133 or go to www.gamstop.co.uk to be excluded from all UK-regulated gambling websites.

Dec 11, 2024 - 11:01
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NFL betting tips: San Francisco 49ers vs Los Angeles Rams preview and picks

With the bye weeks out of the way, the 2024 NFL season is nearing a thrilling conclusion and the San Francisco 49ers and Los Angeles Rams start Week 15 with what should be a cracking NFC West contest at Levi’s Stadium.

Both teams are on the outside looking in as far as the playoffs are concerned – the Rams have a 7-6 record following last week’s brilliant 44-42 win over the Bills while the 6-7 49ers have work to do if they’re to repeat last season’s run to the Super Bowl.

There is little between the two California franchises in the match betting for Thursday’s game but we’re favouring the Niners as part of a bet builder which pays out at 9/1.

GET £20 IN FREE BETS WITH TALKSPORT BET*

San Francisco 49ers v Los Angeles Rams tips

  • San Francisco 49ers Handicap -2.5
  • Over 48.5 Total Match Points
  • Brock Purdy 0ver 0.5 rushing touchdowns

Bet Builder odds: 9/1

49ers should pull away on home turf

This is a high-pressure clash in the context of both teams’ seasons but particularly the 49ers, who have no margin for error whatsoever given their losing record.

While it’s not been a vintage season for Kyle Shanahan’s men, who have been hit by a series of injuries to key players on both offence and defence, they returned to top form in Week 14 to defeat the Chicago Bears and will view this as something of a free hit.

The Rams have won the last two clashes, mounting a fourth-quarter comeback to win 27-24 in Week 3 of this season and winning 21-20 in Santa Clara in January last season, albeit in a game in which 49ers quarterback Brock Purdy was absent.

Purdy has previously led the 49ers to victory over their divisional rivals, doing so at SoFi in September of the 2023 regular season, and he was at his clinical best against the Bears on Sunday, completing 80% of his passes for 325 yards and two touchdowns.

LA are riding high after their victory over the Bills but that was an emotionally draining win for a team who have been inconsistent this season.

Expect points to pile up in Santa Clara

The total is set high at 48.5 but there is every chance these teams combine for a high-scoring contest at the Levi’s.

The 49ers still boast a stout defence but Matthew Stafford and the Rams were good enough to go toe-to-toe with the Bills and, with wide receiver Puka Nacua in red-hot form, LA should help contribute to the scoring.

The Rams have, however, struggled on the defensive side of the ball all season, allowing an average of 25.5 points per game.

Niners QB Purdy could use his legs

The 49ers running backs have been dropping like flies and doubts remain over the health of Isaac Guerendo, who was already filling in for Christian McCaffrey and Jordan Mason.

Guerendo ran in two touchdowns against the Bears but he’s a doubt with a foot sprain, which could force Purdy to take matters into his own hands in the red zone.

Purdy is no stranger to using his legs – he has had four rushing touchdowns this season – all of which came in the Niners last four home games.

GET £20 IN FREE BETS WITH TALKSPORT BET*

*18+ New customers only. Opt in & bet £10+ via mobile on any sports at 2.00+ odds within 7 days. No Cash out. Get 4x £5 Free Bets on selected markets. Free bets expire in 7 days. Card payments & Apple Pay only. T&Cs apply, see below. GambleAware.org | Please gamble responsibly

All odds correct at time of writing

talkSPORT BET Canada

talkSPORT BET is now live in Canada!

Following on from our success in the UK & Ireland, we have now launched in Canada.

All residents outside of Ontario can now sign up and bet with talkSPORT BET.

Bet $10 at odds of +100 and get triple your returns up to $300! – CLAIM HERE

T&Cs: 19+ New customers only. Opt in, bet max $10 on any sport single in 7 days, at odds +100 or greater. If it wins we Triple (x3) your returns, up to $300 in Free Bets, expires in 7 days. T&Cs apply, click for T&Cs. Responsiblegambling.org | Please gamble responsibly

Remember to gamble responsibly

A responsible gambler is someone who:

  • Establishes time and monetary limits before playing
  • Only gambles with money they can afford to lose
  • Never chase their losses
  • Doesn’t gamble if they’re upset, angry or depressed
  • Gamcare – www.gamcare.org.uk
  • GambleAware – www.gambleaware.org

Find our detailed guide on responsible gambling practices here.

For help with a gambling problem, call the National Gambling Helpline on 0808 8020 133 or go to www.gamstop.co.uk to be excluded from all UK-regulated gambling websites.