Drew Barrymore Turns 50! See 20 Photos of the Star Getting Up Close and Personal with Her Celebrity Friends

The actress and talk show host has previously expressed how she loves to be close to others — and it's not an understatement

Drew Barrymore keeps her talk show guests close — and her friends even closer!

The Drew Barrymore Show host — who celebrates her 50th birthday on Saturday, Feb. 22, 2025 — is known for her affectionate interviews, which have garnered mixed reception among viewers. During a chat with Dax Shepard on the show in September 2024, she told the podcaster, "I get in trouble for physical proximity on this show."

She continued, "I guess a lot of people say ‘you’re too touchy’ about me. ... I’m horrified when I hear that, and yet I can’t stop.”

Although she told Entertainment Tonight that she would "try to practice physical distance," she stipulated that she enjoys the company of others. As Barrymore celebrates a new milestone, see 22 photos of the iconic actress cozying up with her many celebrity friends, from Cameron Diaz and Lucy Liu to Jimmy Fallon.

Cameron Diaz and Lucy Liu

Her Charlie's Angels squad Cameron Diaz and Lucy Liu have been showing Barrymore love for years!

Courtney Love

Barrymore and Courtney Love are best friends to this day, and the talk show host is even the godmother of Love's daughter Frances Bean.

Jimmy Fallon

Barrymore and Jimmy Fallon go way back, costarring in the 2005 rom-com Fever Pitch.

Steven Spielberg

Ke Huy Quan and Drew Barrymore gave Steven Spielberg — who directed them as child stars — a smooch on the cheek when they reunited at the 2023 TIME100 Gala.

Natasha Lyonne and Aubrey Plaza

Also at the TIME100 Gala, Barrymore joked around with Natasha Lyonne and Aubrey Plaza.

Ali Wong

She also met up with a glamorous Ali Wong at the TIME100 Gala for a super smiley photo.

Adam Sandler

Three-time costars Barrymore and Adam Sandler's working relationship dates back to 1998's The Wedding Singer.

Jay-Z

At the 2021 Rock & Roll Hall of Fame Induction Ceremony, Barrymore beamed next to inductee Jay-Z.

Cameron Diaz

At Liu's Hollywood Walk of Fame star ceremony, Barrymore and Diaz sat right by each other to support their friend.

Sydney Sweeney

After her appearance on The Drew Barrymore Show, Sydney Sweeney embraced the host on the streets of New York City...

Glen Powell

...and so did Sweeney's Anyone but You costar Glen Powell!

Toni Collette

Barrymore and Toni Collette were not afraid to take loved-up photos during the press tour for their 2015 film Miss You Already.

Hannah Waddingham

Sitting front row at the Christian Siriano show during New York Fashion Week, Barrymore leaned in to take a selfie with Hannah Waddingham.

Jessica Lange

Barrymore held tight to Grey Gardens costar Jessica Lange at the film's Los Angeles premiere in 2009.

Kristen Wiig

At the afterparty for Grey Gardens, Barrymore looked like an Old Hollywood star as she got cheek-to-cheek with Kristen Wiig.

Timothy Olyphant

Barrymore looked lovingly at her Santa Clarita Diet co-lead Timothy Olyphant at the series premiere in 2017.

Liv Hewson

She was also close to her other castmates on the Netflix horror sitcom, like Liv Hewson.

Ben Platt

She supported Ben Platt backstage at the Broadway production of Dear Evan Hansen.

Ross Mathews

It's no surprise that she's so close — literally — with her Drew Barrymore Show co-host Ross Mathews.

Nate Burleson

Barrymore was ecstatic when her Hollywood Squares co-host Nate Burleson showed up to her Paley Museum event in September 2024.